Which of the following antibodies is NOT considered clinically insignificant?

Anti-Fya is considered a clinically significant antibody because it can cause hemolytic transfusion reactions and may lead to significant complications if present in a patient who receives incompatible blood. Antibodies like Anti-Fya react with certain red blood cell antigens, making it important to identify these antibodies during blood typing and crossmatching processes to ensure patient safety.

In contrast, antibodies such as Anti-M, Anti-N, and Anti-Lub are generally considered clinically insignificant. They usually do not cause hemolytic reactions or have minor clinical implications when present, especially when determining transfusion compatibility. This classification helps medical technologists focus on the more clinically relevant antibodies that require further examination during blood transfusion preparations.