TRALI is a transfusion complication associated with fluid accumulation in which part of the body?

Transfusion-related acute lung injury (TRALI) is characterized by sudden onset of respiratory distress and is primarily associated with fluid accumulation in the lungs. This condition typically manifests within six hours of a blood transfusion and results from an immune-mediated response to blood products. Following the transfusion, activated neutrophils migrate to the pulmonary capillaries, leading to increased vascular permeability. This process causes fluid to accumulate in the alveoli, making breathing difficult and decreasing oxygen exchange.

Identifying the lungs as the site of fluid accumulation helps in understanding the pathophysiology of TRALI and emphasizes the importance of monitoring patients for respiratory symptoms following blood transfusions.